Phase i trials are a critical first step in the study of novel cancer therapeutic approaches their primary goals are to identify the recommended dose schedule and pharmacologic behavior of new agents or new combinations of agents and to describe the adverse effects of treatment. The arrival of a book on phase i cancer trials is timely the key strength and uniqueness of this book is as its subtitle describes a practical guide to phase i cancer clinical trials the chapters take the reader in a clear and stepwise manner through the design ethical aspects writing of protocols and conduct of studies. Phase i trials are a critical first step in the study of novel therapeutic approaches they follow years of development in the laboratory and precede phase ii and iii trials where testing of the drug becomes more focused yet is conducted on a wider scale. Phase i cancer clinical trials a practical guide kindle books feb 25 2019 j k rowling media publishing phase i cancer clinical trials a practical guide 2nd edition is an indispensable guide for the specialized world of phase i cancer. Phase i cancer clinical trials by e eisenhauer c twelves and m buyse is 343 pages long and contains three schemas showing procedures for administering drugs pages 144 149 156 and contains four graphs showing titrations resulting in drug toxicity pages 49 56 143 and 147
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